Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

• Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analysis of genome-wide association studies, focusing on stroke cases with an age of onset <60 years.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Adult

African Continental Ancestry Group

genetics

Age of Onset

Aged

Asian Continental Ancestry Group

genetics

Brain Ischemia

complications

genetics

Chromosomes

Human

Pair 10

Computer Simulation

DNA

Intergenic

genetics

European Continental Ancestry Group

genetics

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Male

Middle Aged

Odds Ratio

Polymorphism

Single Nucleotide

Serine Endopeptidases

genetics

metabolism

Stroke

etiology

genetics

Publication and Content Type

ref (subject category)

art (subject category)